Evogene completes first computational discovery of novel microbial genes for insect control

Evogene, a leading company for the improvement of crop productivity and economics for the food and feed industries, announced today a key milestone in its insect control program with the successful completion of the first computational discovery round for microbial genes with insecticidal properties.

The discovery round used a unique computational technology infrastructure consisting of a proprietary microbial-based database and a dedicated analysis platform, BiomeMiner. The candidate genes will be validated against target insects at the company's dedicated R&D site located in St. Louis, Missouri. Validation is expected to be completed next year.

The first computational discovery round using BiomeMiner yielded a set of novel candidate genes with insecticidal properties to be validated against Coleoptera and Lepidoptera insects. These families of insects include some of the most devastating insects to crop yields such as corn rootworm and corn earworm.

In addition to these novel candidate genes, the platform also identified previously known genes that are already recognized for their insecticidal properties, providing a proof of concept for the predictive power of Evogene's discovery platform.

"This milestone in Evogene's insect control program is an important achievement. Within a very short period of time we were able to leverage our knowhow and technology in plant science to tackle the field of microbial traits, a new field for us with significant barriers to innovation," Ofer Haviv, president and CEO of Evogene said. "By formulating unique approaches to data generation and computational analysis, we are paving the path for the future development of new insect control products. The validation of these candidate genes, which is the next significant milestone in the program, will further advance us on this path."

The current market for insect control traits based on microbial genes is estimated at approximately $4.5 billion annually. When inserted into a target crop, these genes and their insecticidal traits provide protection for the plant from certain harmful insects.

Today, most of these products are based on microbial genes derived from one type of bacteria, Bacillus thuringiensis (Bt), to which insects have grown resistant over the years.

The next generation of insect control products that will address this growing resistance will most probably be based on the discovery of microbial genes not derived from the Bt bacteria.

With the microbial gene pool constituting hundreds of millions of potential genes, the challenge of finding novel microbial genes that can form the basis of future insect control products, depends on both compiling the huge amount of relevant data into one integrated database and successfully analyzing this huge diversity.

Evogene has used its core competencies to meet this challenge with the development of a proprietary microbial-based database and BiomeMiner, a data analysis platform.

The database, containing tens of millions of microbial genes, is capable of integrating data from diverse microbial sources including publicly available data and data collections from proprietary experimental samples enriched for insecticidal activity.

A unique feature of the database is the integration capabilities of vast amounts of highly sparse and complex "metagenomics" data.

To process this huge microbial gene pool within the database, the BiomeMiner analysis platform utilizes advanced machine learning algorithms to rapidly identify and prioritize genes with insecticidal properties.

The platform sifts through the vast microbial gene pool in the database and elects a limited number of genes with the potential for insecticidal properties.

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Evogene, Ltd

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